Oral Presentation Clinical Oncology Society of Australia Annual Scientific Meeting 2019

Ten-year quality of life outcomes in men with prostate cancer  (#10)

Nicholas F Ralph 1 2 3 , Shu Kay Ng 4 , Leah Zajdlewicz 1 , Stephen J Lepore 5 , Peter Heathcote 6 , Andrew Kneebone 7 8 , Jeffrey C Dunn 1 3 9 , Suzanne K Chambers 1 3 10
  1. Cancer Council Queensland, Brisbane, QLD, Australia
  2. School of Nursing & Midwifery , University of Southern Queensland, Darling Heights, QLD, Australia
  3. Centre for Health Research, University of Southern Queensland, Darling Heights, QLD, Australia
  4. Menzies Health Institute Queensland, Griffith University, Southport, QLD, Australia
  5. College of Public Health, Temple University, Philadelphia, Pennsylvania, USA
  6. Princess Alexandra Hospital, Woolloongabba, QLD, Australia
  7. University of Sydney, Sydney, NSW, Australia
  8. Royal North Shore Hospital, St Leonards, NSW, Australia
  9. Prostate Cancer Foundation of Australia, Sydney, NSW, Australia
  10. Edith Cowan University, Perth, WA, Australia

Objective: To report physical and mental health-related quality of life (HRQoL), life satisfaction and symptom burden of men over the ten years after prostate cancer diagnosis.

Methods: 1064 (82.4% response) diagnosed with prostate cancer who were pre-treatment and close to diagnosis were recruited. Most men had localised disease (92.1%) at recruitment. Men were assessed over a ten-year period with self-reported HRQoL, life satisfaction and symptom burden using validated questionnaires. Bowel, sexual and urinary function were also assessed. 598 men completed the questionnaires at 10-years.

Results: Three trajectory patterns were identified for physical and mental HRQoL and life satisfaction. Compared with men who reported constantly high physical HRQoL, men with poorer physical health were more likely to receive ADT, have a low income, and multiple comorbidities. Poorer mental HRQOL was differentiated by lower income and multiple comorbidities versus men with high mental HRQoL. Against men with ongoing high satisfaction with life, lower life satisfaction was predicted by younger age, being single, receiving a low income, and multiple comorbidities. Better urinary, bowel, and sexual function were related to better HRQoL and life satisfaction over time.

Conclusions: Androgen deprivation therapy, comorbidities and socioeconomic disadvantage are risk indicators for poorer long-term quality of life after a diagnosis of prostate cancer. Risk indicators need to be incorporated into survivorship care planning. Survivorship interventions need to account for these indicators to ensure men most at risk of poorer physical and mental health can access appropriate care.